Gender Bias Seen In Response To Common Antidepressant

�Women with depression may be a great deal more likely than manpower to get relief from a usually used, inexpensive antidepressant dose, a young national study finds. But many members of both sexes may find that it helps ease their depression symptoms.



The persistence of a gender difference in response to the do drugs - level after the researchers accounted for many complicating factors - suggests that there's a real biological difference in the way the medication affects women compared with work force. The reasons for that difference are still unclear, but farther studies are now examining hormonal variations that may play a role.



The study involved citalopram, a ordinarily used antidepressant that is available both as a generic dose and under the brand name Celexa.



Researchers from the University of Michigan Depression Center and their colleagues from around the country tested the drug's ability to help depression patients achieve remission, or add together relief from their symptoms, in a multi-year study called STAR*D.



The gender differences emerged from a detailed analysis of data from 2,876 men and women world Health Organization had a clear diagnosis of major depression, and took citalopram over a number of weeks, with the doses increasing over time.



In the end, women were 33 percent more likely to achieve a full remission of their depression, despite the fact that women in the study were more hard depressed than the hands when the study began.



The study showed no differences between work force and women in side effects, the amount of time that patients stuck to pickings the dose, or the amount of time it took for them to achieve subsidence of their symptoms.



The young findings, which represent the largest and most tight analysis e'er of gender differences in response to an antidepressant, are promulgated online in the Journal of Psychiatric Research.



Elizabeth Young, M.D., a professor and associate professorship of psychiatry at the U-M Medical School and member of the Depression Center, is the study's lead author. "Other studies have suggested that there are differences between hands and women in answer to different antidepressants, only the evidence has been conflicting," she says. "This study is large sufficiency, and we were able to control for enough complicating factors, that we feel convinced there is a unfeigned difference. These results ingest clear implications for the clinical handling of depression."



Young and her colleagues, including Susan Kornstein, M.D., of Virginia Commonwealth University, and John Rush, M.D., at one time of the University of Texas Southwestern Medical Center at Dallas, conducted the analysis of data from men and women between the ages of 18 and 75, many of whom were being treated by primary care physicians and non psychiatrists. All of the patients had been experiencing depression for years, with the modal length of experience around 12 years.



The study was funded by the National Institute of Mental Health. Unlike many previous industry-sponsored studies of antidepressants, it included a "real domain" sample of people with major natural depression, and did not bar people world Health Organization had a history of suicidal cerebration. The study did not include people with bipolar disorder. Participants in the study could continue with psychotherapy that they had been undergoing before the start of the study, but could take no other antidepressants.



Citalopram is ane of a class of medicines known as SSRIs, or selective serotonin reuptake inhibitors. In earlier decades, gender differences had been seen in studies of patients taking an older generation of drugs called tricyclics, with men attention to respond better to such medications. But for more than 15 years, SSRIs have been the first selection for treating depression.



Although the current study didn't look at hormonal variations between men and women that might accounting for the difference in response to citalopram, Young and her colleagues billet that animate being studies bear shown that estrogen modifies the encephalon systems involved in the activity of serotonin, a key learning ability chemical.



Kornstein is leading further analysis of the STAR*D results to look for possible differences among women according to their menopausal status and their manipulation of internal secretion replacement therapy. Meanwhile, Young's research as a member of the U-M Molecular & Behavioral Neuroscience Institute focuses on the interactions of gender hormones and stress answer in impression and other mood disorders.



Overall, women ar more touched by imprint than men, with about 12 percentage of women suffering from some form of depression in a given year compared with 6 per centum of work force. Depression and other mode disorders are the starring cause of disability among women under the age of 45.



But the study's authors ar quick to caution that their findings don't mean that citalopram should but be used in women. Raw information from the study bear witness that 24 percent of men achieved remission with the drug, compared with 29 per centum of women. The difference in remitment rates grew larger once the researchers adjusted for other factors, but the fact remains that many men were helped.



Rather, they note that STAR*D and other studies have shown that many people with depression want to try on several treatments to find the one that's right for them and will produce lasting results.



That's wherefore a new study called CO-MED has begun. Young and colleagues from U-M and around the country are now enrolling people with slump for this study that will value the impact of combinations of medications. One of the medications in that study is escitalopram, a cousin of citalopram, only it besides includes other common SSRI antidepressants.





More info on the CO-MED study is uncommitted at hypertext transfer protocol://www.depressioncenter.org/research/co-med.asp. Information on STAR*D is available at http://www.nimh.nih.gov/health/trials/practical/stard.



In addition to Young, Kornstein and Rush, the study's authors include Sheila Marcus of the U-M Depression Center, Madhukar Trivedi and Diane Warden of UT-Southwestern, Anne Harvey of Via Christi Research, Stephen Wisniewski and G.K. Balasubramani of the University of Pittsburgh and Maurizio Fava of Harvard Medical School.



Reference: Journal of Psychiatric Research, doi:10.1016/j.jpsychires.2008.07.002



Source: Kara Gavin

httUniversity of Michigan Health System




View do drugs information on Celexa.



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Download Lords Of The New Church

Artist: Lords Of The New Church: mp3 download    Genre(s):  Rock: Punk-Rock     Discography:      Killer Lords    Year: 1985    Tracks: 19 Formed in 1981, the Lords of the New Church had a redoubtable intercontinental stumper rock bloodline. Singer Stiv Bators and guitarist Brian James were institution members of Cleveland's Dead Boys and London's the Damned, respectively, both successful and influential punk rocker pioneers. (Annotation: Much like Keith Richard(s), Stiv spelled his surname both with and without a terminal "s" at various points in his career. Throughout his meter with the Lords, however, he was billed as Bators.) Bassist Dave Tregunna and drummer Nick Turner were veterans of Sham 69 and the Barracudas, which were less seminal simply still well-known. But spell the Lords' music had elements of toughie, it was more than melodic, better-produced, and played with a higher degree of professionalism. This alienated some of the hard-core tinder audience, just brought the Lords a much wider and more than diverse fan theme. The generation of the Lords was in 1980 when Bators and James, having schism from their late bands, renewed an aqcuaintance that began when the Dead Boys opened for the Damned on CBGB dates and an English go. The two experimented for a metre with different round sections, rehearsing shortly with ex-Generation X bassist Tony James and ex-Clash drummer Terry Chimes (how's that for a punk rocker john Rock supergroup?). A batting order of Bators, James, Tregunna, and Damned drummer Rat Scabies played a single 1980 gig as the "Utter Damned Sham Band." But by the meter the Lords' self-titled debut record album appeared in 1982, Turner had replaced Scabies to form the card that would stay fixed passim the band's to the highest degree productive geezerhood. Though the album was well-received, the Lords became more infamous for their live shows, or more than specifically for Bators's crazed give up as a performer. A fan of Iggy Pop, Bators had in his Dead Boys years developed a reputation for being unafraid to danger his life in pursuit of rock and roll & roll glory. He suffered unnumberable onstage injuries during his calling, the most illustrious being the time he reportedly closely hung himself during a Lords show. As the tale goes, a front-runner stunt of Bators' where he looped the mic cord approximately his neck went askew, resulting in his organism clinically dead for several minutes. Nonetheless, Bators survived to phonograph recording 2 more successful albums with the Lords, 1983's Is Nothing Sacred? and 1984's The Method to Our Madness. After this, though, the Lords appeared to lose their originative impetus. They continued to disc periodically including an amusing single where they violated Madonna's "Care a Virgin" and two first-class new tracks for the best-of Killer Lords, just by 1985, the Lords had slowly begun to disintegrate. Tregunna left, was replaced for a time by Grant Fleming, and then returned. A arcsecond guitar player, Alistair Simmons, was added and then pillaged. Turner stop and was replaced by Danny Fury. After 1988, Bators back injury light-emitting diode James to advertize for a permutation singer -- a impermanent one, he claimed -- the Lords rip acrimoniously, simply not earlier Bators played the encore of his last designate wear a T-shirt that eagre an expansion of James' paper ad. Possibilities of whatever future Lords reunions were quashed when Bators died in 1990 of injuries sustained when he was smitten by a car in the streets of Paris.

Peter Kater and R. Carlos Nakai

   
Artist: Peter Kater and R. Carlos Nakai

   Genre(s): 
Other
   

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Discography:


   
 Honorable Sky

   Year:    
Tracks: 8

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The Rascals play Glastonbury set with 'the full shebang'

The Rascals played their second set of the 2008 Glastonbury this afternoon (June 27).

Having played a short, warm-up set before proceedings officially kicked off yesterday, the band promised "the full shebang" for their Other Stage set.

Arriving onstage to the title track of their new album 'Rascalize', the band tore through a longer set with "shebang" as they showcased their debut record.

Playing the likes of 'Bond Girl' and former singles 'Out Of Dreams' and 'Freakbeat Phantom' the band then dedicated a song to one of the growing crowd.

"This is for our mate Jay whose birthday it is, and for the mothers!" declared frontman Miles Kane before 'I'll Give You Sympathy', pointing to his friends and family in the crowd.

The Rascals played:

'Ratcatcher'
'Does Your Husband Know That You're On The Run'
'Bond Girl'
'Out Of Dreams'
'Fear Invicted Into The Perfect Stranger'
'Freakbeat Phantom'
'People Watching'
'Stocking To Suits'
'I'll Give You Sympathy'
'Is It Too Late'

Keep up with all the action from Glastonbury this weekend (June 27-29) as it happens on NME.COM. For news, pictures and blogs keep checking the NME.COM's Glastonbury Festival page. Plus make sure you get next week's issue of NME � on UK newsstands from July 2 � for the ultimate Glastonbury review.

Cary Brothers

   
Artist: Cary Brothers

   Genre(s): 
Indie
   Rock
   

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Discography:


   
 Who You Are

   Year: 2007   
Tracks: 11


   
 Waiting For Your Letter EP

   Year: 2005   
Tracks: 5

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Wry, thoughtful singer/songwriter Cary Brothers bust into the mainstream with the single "Drear Eyes," a resplendently word lay he contributed to 2004's Grammy-winning, hip-artist-showcasing Garden State soundtrack. Born in 1974 to a watercolorist mother and surgeon father, Brothers eschewed the sounds of his native Nashville in favor of Britpop artists like the Cure and the Smiths. Brothers accompanied college at Northwestern University in the early '90s, where he met Zach Braff, the writer, director, and star of Garden State. Both stirred to L.A. subsequently graduation, where Braff rounded out his playing résumé and Brothers partnered with a ally to open a small production company that produced, among other things, the Freddie Prinze, Jr., motion-picture show Sparkler.


By 2002, though, his inherent aptitude to make music had overtaken his drive to fret shoulders with Hollywood insiders. Brothers, world Health Organization by so had developed an appreciation for the country people music he couldn't be daunted with as a kid in Nashville, began playing around L.A. at such venues as the Hotel Cafe, a local stalk for coming singer/songwriters. There he honed the early material that would make headway o'er more than 10,000 buyers for his reverb-ringed spring 2005 EP All the Rage.


Earlier that phonograph recording came out, though, Brothers -- with the serve of brother Braff -- had already taken his sound to the small covert after an appearance on Surgical gown. His swelling popularity, by then best evidenced by the iPod charts, where "Aristocratical Eyes" bust the Top 100 Songs list and topped the kinsfolk chart, was as well helped along by his business acumen. In 2004, he reach upon an idea for connecting with potential listeners: he conceived a disengage, downloadable "birdsong of the week," still uncommitted on his site, that would allow fans of his moody, Coldplay-meets-U2 good to post him feedback on what they liked and what, for them, could use some retooling.


By fall 2005, when a sec EP, Wait for Your Letter, was issued on his Procrastination Music tag, the spike in visits to his website had confirmed that the construct was working. Armed with a strong fan fundament, Brothers released his debut full-length, WHO You Are, in May 2007.

Spears goes home to be with sister

Pop singer Britney Spears has reportedly travelled home to Louisiana in order to be with her younger sister Jamie Lynn when she gives birth.
According to People magazine, the star took an "early morning commercial flight" home with her father Jamie, her brother Bryan and her assistant.
Spears is expected to spend some time at her family's Kentwood home ahead of the birth of her sister's baby.

Adam Carolla gets in "Top Gear"

LOS ANGELES (Hollywood Reporter) - NBC announced Monday morning what listeners to Adam Carolla's radio show have known for a while: The comedian will host the broadcaster's adaptation of the BBC's "Top Gear."


Carolla will join drift racer Tanner Foust and TV construction guru Eric Stromer as the show's presenters. "Gear" targets auto enthusiasts and mixes racing, stunts, challenges and celebrity guests.


NBC announced the show as a pilot in the winter, but the project has not yet been added to the network's year-round schedule, which was unveiled in May.


The original "Gear" premiered in 1977 and is BBC 2's most-watched program in the U.K. The show is broadcast in more than 100 countries and has been airing on BBC America since 2007.


Reuters/Hollywood Reporter